Dr. Christine Disteche is a UW professor of pathology. She is one of the directors of the Cytogenetics and Genomics Laboratory.
Her clinical expertise is in cytogenetics and genome analysis. These clinical tests can detect chromosomal abnormalities – for example, trisomy 21 (an extra copy of chromosome 21, characterizing Down syndrome) or specific anomalies that distinguish cancers.
Patient Care Philosophy
"I aim to provide the most accurate and timely diagnosis of chromosome disorders. The field of cytogenetics and genomics changes quickly, so practitioners must keep current of new developments and research."
Studying abnormalities of the sex chromosomes and their impact on disease
Research in my laboratory focuses on the regulation of the mammalian X chromosome. Males have one X and a Y chromosome; females have two X chromosomes. Over time, a mechanism called "dosage compensation" has evolved so that a normal female's two X chromosomes have the same genetic influence as the single X chromosome of the normal male. This mechanism occurs during embryonic development and depends on stem cell factors.
|University of Liege||Medical education||1976|
|Harvard Medical School - Dept. of Pathology||Fellowship|
|American Board of Medical Genetics||Clinical Cytogenetics||1984|